منابع مشابه
Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats
α-Lipoic acid (LA) is widely used for nutritional supplements as a racemic mixture, even though the R enantiomer is biologically active. After oral administration of the racemic mixture (R-α-lipoic acid (RLA) and S-α-lipoic acid (SLA) mixed at the ratio of 50:50) to rats, RLA showed higher plasma concentration than SLA, and its area under the plasma concentration-time curve from time zero to th...
متن کاملPharmacokinetics of orally administered DL-α-lipoic acid in dogs.
OBJECTIVE To determine the pharmacokinetics of DL-α-lipoic acid in dogs when administered at 3 dosages via 3 methods of delivery. ANIMALS 27 clinically normal Beagles. PROCEDURES In a 3 × 3 factorial Latin square design, 3 dosages (2.5, 12.5, and 25 mg/kg) of DL-α-lipoic acid were administered orally in a capsule form and provided without a meal, in a capsule form and provided with a meal, ...
متن کاملΑ-lipoic Acid Reduces Neurogenic Hypertension by Blunting
22 We previously reported that ACE2 compensatory activity is impaired by the 23 disintegrin and metalloprotease 17 (ADAM17) and lack of ACE2 is associated 24 with oxidative stress in neurogenic hypertension. To investigate the relationship 25 between ADAM17 and oxidative stress, Neuro2A cells were treated with Ang-II 26 (100 nM) 24 h after vehicle or α-lipoic acid (LA: 500 μM). ADAM17 expressio...
متن کاملTherapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid
Silver (SN) nanoparticles were re‐dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha‐ Lipoic acid (LA). The nanoparticle ‐ LA complex (SN‐LA) was characterized using SEM. SN‐ LA exhibited DPPH radical scavenging activity in vitro and anti‐ inflammatory activity against acute and chronic paw models of edema in mice. SN‐LA protected ...
متن کاملOverproduction of α-Lipoic Acid by Gene Manipulated Escherichia coli
Alpha-lipoic acid (LA) is an important enzyme cofactor widely used by organisms and is also a natural antioxidant for the treatment of pathologies driven by low levels of endogenous antioxidants. In order to establish a safer and more efficient process for LA production, we developed a new biological method for LA synthesis based on the emerging knowledge of lipoic acid biosynthesis. We first c...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1959
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.7.750